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Nine Respiratory Pathogens and Inflammatory Factors in the Diagnosis of Pediatric Acute Respiratory Infection

Zhong Feng, Yongmei Fang, Jingjing Zhang, Jin Wu, Xiubing Tao, Yan Xu, Jun Zhao


Objective To clarify the epidemiological characteristics of pediatric respiratory infection in our hospital and explore the diagnosis of pediatric acute respiratory infection (ARI) by the clinical characteristics of pediatric mixed pathogen infection and the serum levels of inflammatory factors.

Methods Blood samples of inpatient children with ARI from June 2017 to June 2019. Nine IgM of the respiratory pathogens were detected by indirect immunofluorescence assay (IFA), and the serum levels of IL-8, TNF-α, IFN-γ in children with mixed infection were detected by enzyme-linked immunosorbent assay (ELISA).

Results A total of 5,122 children with ARI was included, the overall detection rate 38.89%. The overall detection rate of nine respiratory pathogens was 50.96%. MP detection rate was highest in the 0-3 years age group and the 4-14 years age group. There were 251 cases of mixed infection, the detection rate of MP combined with RSV was the highest. The serum levels of CRP, IL-8, TNF -α and IFN-γ were increased to varying degrees..

Conclusion The detection rate of MP was the highest in children with ARI in our hospital. The serum level of IL-8 could be used as an measure of the severity of ARI.


Acute respiratory infection;Nine Respiratory Pathogens;Inflammatory Factors

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