Gold nanoinsulin particles effect on glucose level of induced diabetic mice and body physiology

Bashir Ahmad, Zaheer Ud Din, Muhammad Nasir Khan Khattak, Syed Imam Shah, Mohamed Y. Zaky, Gehad R. Abdelbaset, Pengyu Su, Ata Ur Rehman, Faizur Rahman, Mohammed Alshwmi, Syed Rafiq Hussain, Manzoor Ahmad, Bakhtawar Khan, Akbar Husain, Sadeeq Ahmad, Tariq Mehmood

Abstract


Diabetes mellitus is characterized by hyperglycemia is a leading cause of death in both developed and underdeveloped countries. Few therapies are in practice, but rapid and effective control is still lacking. In the current study, we aim to check the effect of Gold nanoinsulin on glucose level, blood complete picture (CP) and blood biochemistry in alloxan induced diabetic mice. Gold naninsulin (NI) were injected into diabetic mice and glucose levels were measured. At the end of the experiment the blood was collected from the heart and performed the blood CP and blood biochemistry. Our results show that after treatment with nanoinsulin subcutaneously, the blood glucose level was comparable to normal control with 15 minutes while regular insulin takes 45 minutes. In CP and blood biochemistry, NI only decrease hemoglobin significantly compared to all groups. Gold nanoinsulin proved a difference and rapid therapy for controlling hyperglycemia.

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